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PLoS ONE has just published a study which defines a gene locus on chromosome 1 that predicts prognosis of brain tumor patients and may even set the basis for the development of more efficient drugs to combat brain cancer. Clinical and basic researchers from the University Hospital Basel, Switzerland, the Heinrich Heine University Dusseldorf, Germany, and the Emory University Atlanta, USA have defined the Notch2 gene as candidate gene for brain tumor development. The study was coordinated by Adrian Merlo, neurosurgeon at the University Hospital Basel.

The Notch2 locus highly predicts survival in subgroups of brain tumor patients. This gene is an important regulator of developmental processes. Taking advantage of a complex DNA duplication involving the Notch2 gene, the researchers developed a molecular assay that unambiguously distinguishes prognostically favorable brain tumor cases from cases that show rapid tumor progression.

In ongoing studies, the Basel researchers, supported by Ruth Chiquet from the Friedrich Miescher Institute, have found that Notch2 upregulates the tenascin-C gene which is well known to play a critical role in brain tumorigenesis. This new brain tumor pathway does not only offer precise diagnostic information, but also defines new targets for molecular intervention to develop drugs against this severe human disease.

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Article adapted by Medical News Today from original press release.
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The following press release refers to an upcoming article in PLoS ONE. The release has been provided by the article authors and/or their institutions. Any opinions expressed in this are the personal views of the contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the release and article and your use of such information.

Citation: Boulay J-L, Miserez AR, Zweifel C, Sivasankaran B, Kana V, et al (2007) Loss of NOTCH2 Positively Predicts Survival in Subgroups of Human Glial Brain Tumors. PLoS ONE 2(6): e576. doi:10.1371/journal.pone.0000576

LINK TO THE PUBLISHED ARTICLE: http://www.plosone.org/doi/pone.0000576

Contact: Professor Adrian Merlo
Public Library of Science